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- Title
Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa.
- Authors
Hawkridge, Tony; Scriba, Thomas J; Gelderbloem, Sebastian; Smit, Erica; Tameris, Michele; Moyo, Sizulu; Lang, Trudie; Veldsman, Ashley; Hatherill, Mark; Merwe, Linda van der; Fletcher, Helen A; Mahomed, Hassan; Hill, Adrian V S; Hanekom, Willem A; Hussey, Gregory D; McShane, Helen
- Abstract
The efficacy of bacille Calmette-Guérin (BCG) may be enhanced by heterologous vaccination strategies that boost the BCG-primed immune response. One leading booster vaccine, MVA85A (where "MVA" denotes "modified vaccinia virus Ankara"), has shown promising safety and immunogenicity in human trials performed in the United Kingdom. We investigated the safety and immunogenicity of MVA85A in mycobacteria-exposed--but Mycobacterium tuberculosis-uninfected--healthy adults from a region of South Africa where TB is endemic.
- Publication
The Journal of infectious diseases, 2008, Vol 198, Issue 4, p544
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/590185