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- Title
Anti-ganglioside antibody induction by swine (A/NJ/1976/H1N1) and other influenza vaccines: insights into vaccine-associated Guillain-Barré syndrome.
- Authors
Nachamkin, Irving; Shadomy, Sean V; Moran, Anthony P; Cox, Nancy; Fitzgerald, Collette; Ung, Huong; Corcoran, Adrian T; Iskander, John K; Schonberger, Lawrence B; Chen, Robert T
- Abstract
Receipt of an A/NJ/1976/H1N1 "swine flu" vaccine in 1976, unlike receipt of influenza vaccines used in subsequent years, was strongly associated with the development of the neurologic disorder Guillain-Barré syndrome (GBS). Anti-ganglioside antibodies (e.g., anti-GM(1)) are associated with the development of GBS, and we hypothesized that the swine flu vaccine contained contaminating moieties (such as Campylobacter jejuni antigens that mimic human gangliosides or other vaccine components) that elicited an anti-GM(1) antibody response in susceptible recipients.
- Publication
The Journal of infectious diseases, 2008, Vol 198, Issue 2, p226
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/589624