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- Title
High-dose amphotericin B with flucytosine for the treatment of cryptococcal meningitis in HIV-infected patients: a randomized trial.
- Authors
Bicanic, Tihana; Wood, Robin; Meintjes, Graeme; Rebe, Kevin; Brouwer, Annemarie; Loyse, Angela; Bekker, Linda-Gail; Jaffar, Shabbar; Harrison, Thomas
- Abstract
The standard therapy for human immunodeficiency virus (HIV)-associated cryptococcal meningitis of amphotericin B (AmB; 0.7 mg/kg per day) plus flucytosine frequently takes >2 weeks to sterilize the cerebral spinal fluid, and acute mortality remains high. A dosage range for AmB of 0.7-1 mg/kg per day is noted in current guidelines, but there are no data comparing 0.7 mg/kg per day with 1 mg/kg per day.
- Publication
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2008, Vol 47, Issue 1, p123
- ISSN
1537-6591
- Publication type
Journal Article
- DOI
10.1086/588792