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- Title
Antigenic profiling of a Chlamydia trachomatis gene-expression library.
- Authors
Follmann, Frank; Olsen, Anja Weinreich; Jensen, Klaus Thorleif; Hansen, Paul Robert; Andersen, Peter; Theisen, Michael
- Abstract
The obligate intracellular bacterium Chlamydia trachomatis is the causative agent of sexually transmitted chlamydia infections. A panel of 116 recombinant C. trachomatis proteins was evaluated comparatively to characterize both cell-mediated and humoral immune responses in patients with confirmed C. trachomatis genital infection. The antigens identified were categorized as being recognized exclusively by T cells (CT004, CT043, CT184, CT509, and CT611), B cells (CT082, CT089, CT322, CT396, and CT681), or both T cells and B cells (CT110 and CT443). This grouping of C. trachomatis antigens was correlated to their predicted cellular localization. The comparative evaluation presented here indicates that T cell antigens are located in all bacterial compartments, whereas antibody targets are mainly localized to the outer membrane (P = .0013). Overall, we have identified 5 T cell antigens, 5 B cell antigens, and 2 T/B cell antigens that are potential components for a future chlamydia vaccine.
- Publication
The Journal of infectious diseases, 2008, Vol 197, Issue 6, p897
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/528378