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- Title
Gliotoxin production in Aspergillus fumigatus contributes to host-specific differences in virulence.
- Authors
Spikes, Sara; Xu, Ran; Nguyen, C Kim; Chamilos, Georgios; Kontoyiannis, Dimitrios P; Jacobson, Raymond H; Ejzykowicz, Daniele E; Chiang, Lisa Y; Filler, Scott G; May, Gregory S
- Abstract
Gliotoxin is a epipolythiodioxopiperazine toxin that is made by the filamentous fungus Aspergillus fumigatus. Gliotoxin has a wide range of effects on metazoan cells in culture, including induction of apoptosis through inhibition of Nf-kappaB, and inhibition of superoxide production by phagocytes. These activities have led to the proposal that gliotoxin contributes to pathogenesis during invasive aspergillosis. We tested this hypothesis by creating isogenic strains of gliotoxin-producing and nonproducing strains.
- Publication
The Journal of infectious diseases, 2008, Vol 197, Issue 3, p479
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/525044