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- Title
Greater tenofovir-associated renal function decline with protease inhibitor-based versus nonnucleoside reverse-transcriptase inhibitor-based therapy.
- Authors
Goicoechea, Miguel; Liu, Shanshan; Best, Brookie; Sun, Shelly; Jain, Sonia; Kemper, Carol; Witt, Mallory; Diamond, Catherine; Haubrich, Richard; Louie, Stan; California Collaborative Treatment Group 578 Team
- Abstract
Plasma concentrations of tenofovir increase when the drug is coadministered with some ritonavir-boosted protease inhibitors (PI/r). We hypothesized that tenofovir disoproxil fumarate (TDF)-treated patients taking PI/r-based regimens would have a greater decline in renal function than patients receiving nonnucleoside reverse-transcriptase inhibitor (NNRTI)-based therapy.
- Publication
The Journal of infectious diseases, 2008, Vol 197, Issue 1, p102
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/524061