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- Title
HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads.
- Authors
Baeten, Jared M; Chohan, Bhavna; Lavreys, Ludo; Chohan, Vrasha; McClelland, R Scott; Certain, Laura; Mandaliya, Kishorchandra; Jaoko, Walter; Overbaugh, Julie
- Abstract
We investigated the effect of human immunodeficiency virus type 1 (HIV-1) subtype on disease progression among 145 Kenyan women followed from the time of HIV-1 acquisition. Compared with those infected with subtype A, women infected with subtype D had higher mortality (hazard ratio, 2.3 [95% confidence interval, 1.0-5.6]) and a faster rate of CD4 cell count decline (P=.003). The mortality risk persisted after adjustment for plasma HIV-1 load. There were no differences in plasma viral load by HIV-1 subtype during follow-up. HIV-1 subtype D infection is associated with a >2-fold higher risk of death than subtype A infection, in spite of similar plasma HIV-1 loads.
- Publication
The Journal of infectious diseases, 2007, Vol 195, Issue 8, p1177
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/512682