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- Title
Stage-specific adaptation of hypermutable Pseudomonas aeruginosa isolates during chronic pulmonary infection in patients with cystic fibrosis.
- Authors
Hogardt, Michael; Hoboth, Christina; Schmoldt, Sabine; Henke, Christine; Bader, Lutz; Heesemann, Jürgen
- Abstract
Pseudomonas aeruginosa (PA) strains with defective DNA mismatch repair genes generate numerous bacterial variants because of high mutation rates. In cystic fibrosis (CF), such mutator strains may lead to the rapid selection of survivors that are specifically adapted to the hostile environment of the inflamed CF lung.
- Publication
The Journal of infectious diseases, 2007, Vol 195, Issue 1, p70
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/509821