We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia.
- Authors
Adewoye, Adeboye H; Nolan, Vikki G; Ma, Qianli; Baldwin, Clinton; Wyszynski, Diego F; Farrell, John J; Farrer, Lindsay A; Steinberg, Martin H
- Abstract
Infection and bacteremia are common in sickle cell disease. We hypothesized that, consistent with evidence for the genetic modulation of other disease complications, the risk of developing bacteremia might also be genetically modulated. Accordingly, we studied the association of single nucleotide polymorphisms (SNPs) in candidate genes with the risk of bacteremia in sickle cell anemia. We found significant associations with SNPs in IGF1R and genes of the TGF-beta /BMP pathway (BMP6, TGFBR3, BMPR1A, SMAD6 and SMAD3). We suggest that both IGF1R and the TGF-beta /BMP pathway could play important roles in immune function in sickle cell anemia and their polymorphisms may help identify a "bacteremia-prone" phenotype.
- Publication
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2006, Vol 43, Issue 5, p593
- ISSN
1537-6591
- Publication type
Journal Article
- DOI
10.1086/506356