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- Title
Nitazoxanide for the treatment of Clostridium difficile colitis.
- Authors
Musher, Daniel M; Logan, Nancy; Hamill, Richard J; Dupont, Herbert L; Lentnek, Arnold; Gupta, Arvind; Rossignol, Jean-Francois
- Abstract
Clostridium difficile colitis has increased in incidence and severity, and treatment failure with metronidazole therapy has increasingly been documented. It is uncertain whether treatment with vancomycin is more effective than treatment with metronidazole, but concern over the emergence of vancomycin resistance has motivated the search for alternative therapy. Nitazoxanide, a nitrothiazolide, blocks anaerobic metabolism of eukaryocyes and effectively treats intestinal infestation due to Cryptosporidium or Giardia species. At low concentrations, this compound inhibits C. difficile in vitro.
- Publication
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2006, Vol 43, Issue 4, p421
- ISSN
1537-6591
- Publication type
Journal Article
- DOI
10.1086/506351