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- Title
Virological response to highly active antiretroviral therapy is unaffected by antituberculosis therapy.
- Authors
Breen, Ronan A M; Miller, R F; Gorsuch, T; Smith, C J; Ainsworth, J; Ballinger, J; Swaden, L; Cropley, I; Johnson, M A; Lipman, M C I
- Abstract
We compared 156 human immunodeficiency virus (HIV)-infected patients who had tuberculosis with control populations of similar size. Of 111 patients with HIV infection and tuberculosis who received highly active antiretroviral therapy (HAART) and therapy for tuberculosis concurrently, 92 (83%) achieved or maintained virus loads of <50 copies/mL, and 99 (89%) achieved or maintained a >or=2 log10 reduction in virus load after 6 months. Virological response and changes in CD4 cell count were equivalent to those in 111 matched HIV-infected subjects without tuberculosis starting HAART. Tuberculosis recurrence rates were similar to those found in an HIV-uninfected population of 156 subjects (3% and 1%, respectively). Treatment for HIV and tuberculosis does not compromise outcomes for either disease.
- Publication
The Journal of infectious diseases, 2006, Vol 193, Issue 10, p1437
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/503437