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- Title
Normal CD16 expression and phagocytosis of Mycobacterium avium complex by monocytes from a current cohort of HIV-1-infected patients.
- Authors
Jaworowski, Anthony; Ellery, Philip; Maslin, Clare L; Naim, Eman; Heinlein, Amy Candy; Ryan, Claire E; Paukovics, Geza; Hocking, Jane; Sonza, Secondo; Crowe, Suzanne M
- Abstract
Monocyte phenotype and function were measured in whole blood sampled from a current cohort of human immunodeficiency virus (HIV)-infected individuals attending a large, metropolitan, university-affiliated hospital. There was no significant difference in the prevalence of CD16+ monocytes or the capacity of monocytes to ingest heat-killed Mycobacterium avium complex between these individuals and HIV-uninfected control subjects, regardless of viral load, current CD4+ T cell count, nadir CD4+ T cell count, or time since diagnosis of HIV infection. CD16+ monocyte prevalence was, however, elevated in patients not currently receiving antiretroviral therapy. We conclude that HIV type 1 infection in the setting of highly active antiretroviral therapy is associated with normal monocyte function and phenotype.
- Publication
The Journal of infectious diseases, 2006, Vol 193, Issue 5, p693
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/500367