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- Title
Low risk of hemolytic uremic syndrome after early effective antimicrobial therapy for Shigella dysenteriae type 1 infection in Bangladesh.
- Authors
Bennish, Michael L; Khan, Wasif A; Begum, Monira; Bridges, Emily A; Ahmed, Sabeena; Saha, Debasish; Salam, Mohammad A; Acheson, David; Ryan, Edward T
- Abstract
Hemolytic uremic syndrome (HUS) may complicate up to 15% of cases of Shiga toxin (Stx)-expressing enterohemorrhagic Escherichia coli (STEC) O157:H7 infections in children. Administration of antimicrobials has been reported to increase the risk of STEC-associated HUS by >10-fold, presumably by increasing the expression and release of Stx by dying STEC bacteria. Shigella dysenteriae type 1 also expresses Stx. However, the effect of antimicrobial therapy on Stx release and the risk of HUS in humans is unknown.
- Publication
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2006, Vol 42, Issue 3, p356
- ISSN
1537-6591
- Publication type
Journal Article
- DOI
10.1086/499236