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- Title
Invasive infections with Haemophilus influenzae serotype a containing an IS1016-bexA partial deletion: possible association with virulence.
- Authors
Kapogiannis, Bill G; Satola, Sarah; Keyserling, Harry L; Farley, Monica M
- Abstract
Recent reports of invasive Haemophilus influenzae non-b capsular serotypes in the era since development of conjugate vaccines have prompted concern about serotype replacement. Unusual clusters of invasive infection due to H. influenzae serotype a with clinical features that resemble those of infection due to H. influenzae serotype b have been described. A unique feature often associated with more-virulent H. influenzae serotype a isolates is the IS1016-bexA partial deletion, which was previously identified in the capsule locus of H. influenzae serotype b strains. We report the clinical, epidemiologic, and molecular genetic features of 2 cases of severe disease caused by H. influenzae serotype a.
- Publication
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2005, Vol 41, Issue 11, pe97
- ISSN
1537-6591
- Publication type
Journal Article
- DOI
10.1086/498028