We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection.
- Authors
Yakub, Imtiaz; Lillibridge, Kristy M; Moran, Ana; Gonzalez, Omar Y; Belmont, John; Gibbs, Richard A; Tweardy, David J
- Abstract
Infection with the flavivirus West Nile virus (WNV) is a growing problem across the United States, where there is a case-fatality rate of 15%-29% in individuals >70 years old and no consistently effective treatment. Susceptibility to WNV disease in inbred strains of mice was mapped to a nonsense mutation in the gene encoding the 1b isoform of 2'-5'-oligoadenylate synthetase (OAS), a member of the OAS/RNase L system of innate viral resistance. Genetic susceptibility to severe WNV disease in humans has not been determined.
- Publication
The Journal of infectious diseases, 2005, Vol 192, Issue 10, p1741
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/497340