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- Title
The novel oral typhoid vaccine M01ZH09 is well tolerated and highly immunogenic in 2 vaccine presentations.
- Authors
Kirkpatrick, Beth D; Tenney, Katherine M; Larsson, Catherine J; O'Neill, J Patrick; Ventrone, Cassandra; Bentley, Matthew; Upton, Anthony; Hindle, Zoe; Fidler, Christine; Kutzko, Deborah; Holdridge, Regan; Lapointe, Casey; Hamlet, Sandra; Chatfield, Steven N
- Abstract
M01ZH09 (Salmonella enterica serovar Typhi [Ty2 aroC(-) ssaV(-)] ZH9) is a live oral-dose typhoid vaccine candidate. M01ZH09 was rationally modified with 2 independently attenuating mutations, including a novel mutation in Salmonella pathogenicity island (SPI)-2. We demonstrate that M01ZH09, in a single oral dose, is well tolerated and prompts broad immune responses, regardless of whether prevaccination with a bicarbonate buffer is given.
- Publication
The Journal of infectious diseases, 2005, Vol 192, Issue 3, p360
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/431605