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- Title
Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases.
- Authors
Williams, Thomas N; Mwangi, Tabitha W; Wambua, Sammy; Alexander, Neal D; Kortok, Moses; Snow, Robert W; Marsh, Kevin
- Abstract
The gene for sickle hemoglobin (HbS) is a prime example of natural selection. It is generally believed that its current prevalence in many tropical populations reflects selection for the carrier form (sickle cell trait [HbAS]) through a survival advantage against death from malaria. Nevertheless, >50 years after this hypothesis was first proposed, the epidemiological description of the relationships between HbAS, malaria, and other common causes of child mortality remains incomplete.
- Publication
The Journal of infectious diseases, 2005, Vol 192, Issue 1, p178
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/430744