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- Title
CD4<sub>+</sub> T Cell Responses in HIV-Exposed Seronegative Women Are Qualitatively Distinct from Those in HIV-Infected Women.
- Authors
Alimonti, Judie B.; Koesters, Sandra A.; Kimani, Joshua; Matu, Lucy; Wachihi, Charles; Plummer, Francis A.; Fowke, Keith R.
- Abstract
The immune response of human immunodeficiency virus (HIV)-exposed seronegative (ESN) women may be qualitatively different from that in those infected with HIV (HIV+). In a cohort of female commercial sex workers in Nairobi, Kenya, we found significantly lower (P ≤ .01) levels of CD4+-specific immune activation and apoptosis in the ESN women compared with those in the HIV+-women. Compared with the HIV+-women, a lower proportion of the ESN women showed p24 peptide pool responses by the short-term, CD4+-specific, interferon (IFN)-γ intracellular cytokine staining assay, whereas the proportion showing responses by the long-term, CD8+-depleted T cell proliferation assay was similar. Interestingly, the ESN responders had a 4.5-fold stronger proliferation response (P = .002) than the HIV+ group. These data suggest that, compared with those in HIV+ women, CD4+ T cells in ESN women have a much greater ability to proliferate in response to p24 peptides.
- Publication
Journal of Infectious Diseases, 2005, Vol 191, Issue 1, p20
- ISSN
0022-1899
- Publication type
Academic Journal
- DOI
10.1086/425998