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- Title
Evaluation of combined live, attenuated respiratory syncytial virus and parainfluenza 3 virus vaccines in infants and young children.
- Authors
Belshe, Robert B; Newman, Frances K; Anderson, Edwin L; Wright, Peter F; Karron, Ruth A; Tollefson, Sharon; Henderson, Frederick W; Meissner, H Cody; Madhi, Shabir; Roberton, Don; Marshall, Helen; Loh, Richard; Sly, Peter; Murphy, Brian; Tatem, Joanne M; Randolph, Valerie; Hackell, Jill; Gruber, William; Tsai, Theodore F
- Abstract
We evaluated a combination respiratory syncytial virus (RSV) and parainfluenza 3 virus (PIV3) live, attenuated intranasal vaccine for safety, viral replication, and immunogenicity in doubly seronegative children 6-18 months old. RSV cpts-248/404 and PIV3-cp45 vaccines were combined in a dose of 10(5) plaque-forming units of each per 0.5-mL dose and compared with monovalent vaccines or placebo. The virus shedding pattern of RSV was not different between monovalent RSV cpts-248/404 vaccine and combination vaccine. Modest reductions in the shedding of PIV3-cp45 vaccine virus were found after the administration of RSV cpts-248/404 and PIV3-cp45 vaccine, relative to monovalent PIV3 vaccine; 16 (76%) of 21 children given combination vaccine shed PIV3-cp45 versus 11 (92%) of 12 of those given monovalent PIV3 vaccine. Both vaccines were immunogenic, and antibody responses were similar between the monovalent groups and the combination group. Combined RSV/PV3 vaccine is feasible for simultaneous administration, and further studies are warranted.
- Publication
The Journal of infectious diseases, 2004, Vol 190, Issue 12, p2096
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/425981