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- Title
Impaired T helper 2 response to aeroallergen in helminth-infected patients with asthma.
- Authors
Araujo, Maria Ilma A S; Hoppe, Bradford; Medeiros, Manoel, Jr; Alcântara, Leda; Almeida, Maria Cecília; Schriefer, Albert; Oliveira, Ricardo R; Kruschewsky, Ramon; Figueiredo, Joanemile P; Cruz, Alvaro A; Carvalho, Edgar M
- Abstract
Helminthic infections have been shown to inhibit allergy skin-prick tests and to modify the course of asthma. We evaluated Dermatophagoides pteronyssinus-specific immune responses in patients with asthma by measuring levels of T helper 2 (Th2) cytokines in peripheral blood mononuclear cell (PBMC) cultures. PBMCs from Schistosoma mansoni-infected patients with asthma living in an area of polyhelminthic endemicity produced lower levels of interleukin (IL)-5 and IL-4 in response to D. pteronyssinus antigen (Ag) 1 than did PBMCs from helminth-free patients with asthma. In contrast, D. pteronyssinus Ag 1-specific production of IL-10 was higher in helminth-infected patients than in helminth-free patients. The addition of recombinant human IL-10 to D. pteronyssinus Ag 1-stimulated cultures of PBMCs from helminth-free patients led to down-modulation of production of IL-5. After helminth-infected patients with asthma received antihelminthic treatment, there was down-modulation of D. pteronyssinus Ag 1-specific production of IL-10 in vitro. S. mansoni-infected patients with asthma produce lower levels of Th2 cytokines than do helminth-free patients with asthma, and this modulation is likely done by IL-10.
- Publication
The Journal of infectious diseases, 2004, Vol 190, Issue 10, p1797
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/425017