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- Title
Randomized, controlled dose-optimization studies of dihydroartemisinin-piperaquine for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand.
- Authors
Ashley, Elizabeth A; Krudsood, Srivicha; Phaiphun, Lucy; Srivilairit, Siripan; McGready, Rose; Leowattana, Wattana; Hutagalung, Robert; Wilairatana, Polrat; Brockman, Alan; Looareesuwan, Sornchai; Nosten, Francois; White, Nicholas J
- Abstract
Dihydroartemisinin-piperaquine (DP) is a new and relatively inexpensive artemisinin-containing fixed-combination antimalarial treatment. An adult treatment course contained 6.4 mg/kg dihydroartemisinin (DHA), which is >40% lower than the level in most artemisinin-containing combinations. This raised the possibility that the efficacy of the current coformulation may not be optimal in the treatment of multidrug-resistant falciparum malaria.
- Publication
The Journal of infectious diseases, 2004, Vol 190, Issue 10, p1773
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/425015