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- Title
Deletion in the Shigella enterotoxin genes further attenuates Shigella flexneri 2a bearing guanine auxotrophy in a phase 1 trial of CVD 1204 and CVD 1208.
- Authors
Kotloff, Karen L; Pasetti, Marcela F; Barry, Eileen M; Nataro, James P; Wasserman, Steven S; Sztein, Marcelo B; Picking, William D; Levine, Myron M
- Abstract
We created a live, attenuated, oral Shigella vaccine by constructing a lineage of guanine auxotrophs and conducted a double-blind, placebo-controlled trial to ascertain (1) the attenuation profile of Delta guaBA Shigella flexneri 2a, which harbors deletions in the guanine nucleotide synthesis pathway (CVD 1204); (2) additional attenuation conferred by deletions in set and sen genes encoding Shigella enterotoxins (ShETs) 1 and 2, respectively (CVD 1208); and (3) the relative immunogenicity of these constructs.
- Publication
The Journal of infectious diseases, 2004, Vol 190, Issue 10, p1745
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/424680