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- Title
Immune responses to Bacillus anthracis protective antigen in patients with bioterrorism-related cutaneous or inhalation anthrax.
- Authors
Quinn, Conrad P; Dull, Peter M; Semenova, Vera; Li, Han; Crotty, Shane; Taylor, Thomas H; Steward-Clark, Evelene; Stamey, Karen L; Schmidt, Daniel S; Stinson, Kelly Wallace; Freeman, Alison E; Elie, Cheryl M; Martin, Sandra K; Greene, Carolyn; Aubert, Rachael D; Glidewell, John; Perkins, Bradley A; Ahmed, Rafi; Stephens, David S
- Abstract
Anti-protective antigen (PA) immunoglobulin (Ig) G, toxin neutralization, and PA-specific IgG memory B cell responses were studied in patients with bioterrorism-related cutaneous or inhalation anthrax and in a patient with laboratory-acquired cutaneous anthrax. Responses were determined for >1 year after the onset of symptoms. Eleven days after the onset of symptoms (15 days after likely exposure), anti-PA IgG was detected in 16 of 17 patients with confirmed or suspected clinical anthrax who were tested. Anti-PA IgG remained detectable 8-16 months after the onset of symptoms in all 6 survivors of inhalation anthrax and in 7 of 11 survivors of cutaneous anthrax who were tested. Anti-PA IgG levels and serum toxin neutralizing activity were strongly associated (R2=0.83). PA-specific IgG memory B cells were detectable in all 6 survivors of inhalation anthrax but in only 2 of 7 patients with cutaneous anthrax who were tested. Anti-PA IgG is an important diagnostic marker of anthrax, a predictor of serum anti-toxin activity, and a marker of immunological memory against anthrax.
- Publication
The Journal of infectious diseases, 2004, Vol 190, Issue 7, p1228
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/423937