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- Title
Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors.
- Authors
Ylisastigui, Loyda; Coull, Jason J; Rucker, Victor C; Melander, Christian; Bosch, Ronald J; Brodie, Scott J; Corey, Lawrence; Sodora, Donald L; Dervan, Peter B; Margolis, David M
- Abstract
The persistence of human immunodeficiency virus (HIV) type 1 within resting CD4+ T cells poses a daunting therapeutic challenge. Histone deacetylase (HDAC)-1, a chromatin-remodeling enzyme that can mediate gene silencing, is recruited to the HIV-1 long terminal repeat by the host transcription factor LSF. Pyrrole-imidazole polyamides, small molecules that target specific DNA sequences, can access the nucleus of cells and specifically block transcription-factor binding.
- Publication
The Journal of infectious diseases, 2004, Vol 190, Issue 8, p1429
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/423822