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- Title
Requirement of Interleukin-17A for Systemic Anti--Candida albicans Host Defense in Mice.
- Authors
Weitao Huang; Li Na; Fidel, Paul L.; Schwarzenberger, Paul
- Abstract
T cells are required for normal host defense against fungal infection, and individuals with T cell-deficiency syndromes are highly susceptible to fungal pathogens. Interleukin (IL)-17A is a proinflammatory cytokine that interconnects myeloid and lymphoid host defense. The role of murine (m) IL-17A/mIL-17A receptor (R) interactions was evaluated in a murine model of systemic candidiasis. In response to systemic challenge with Candida albicans, expression of mIL-17A was induced, and IL-17AR knockout (IL-17AR-/-) mice had dosedependent, substantially reduced survival. Fungal burden in the kidneys of IL-17AR-/- mice was dramatically increased (25-fold at 96 h). In IL-17AR-/- mice, both mobilization of peripheral neutrophils and their influx to infected organs were significantly impaired and delayed. In vivo expression of mIL-17A protected normal mice from a lethal dose of C. albicans (100% at day 7 and 65% at day 42). The data suggest that the mIL-17A/mIL-17AR system is required for normal fungal host defense in vivo. IL-17A could have potential as a therapeutic cytokine for systemic C. albicans infections in immunocompromised patients with cancer or advanced acquired immunodeficiency syndrome.
- Publication
Journal of Infectious Diseases, 2004, Vol 190, Issue 3, p624
- ISSN
0022-1899
- Publication type
Academic Journal
- DOI
10.1086/422329