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- Title
Immune Responses and Antibody Decay after Immunization of Adolescents and Adults with an Acellular Pertussis Vaccine: The APERT Study.
- Authors
Thuan Le; Cherry, James D.; Swei-Ju Chang; Knoll, Maria Deloria; Lee, Martin L.; barenkamp, Steve; Bernstein, David; Edelman, Robert; Edwards, Kathyrn M.; Greenberg, David; Keitel, Wendy; Treanor, John; Ward, Joel I.
- Abstract
As part of a prospective acellular pertussis (ACP) vaccine efficacy trial, 5 serum samples were obtained, over an 18-month period, from 101 ACP-vaccine recipients and 99 control subjects, to assess ACP antibody response and decay. Immunoglobulin (Ig) G and IgA antibodies to pertussis toxin (PT), filamentous hemagglutinin (FHA), pertactin (PRN), and fimbriae 2/3 (FIM) were measured by enzyme-linked immunosorbant assay, and titers of agglutinin were determined. Of the subjects, 16%-19% had preimmunization values of antibodies to PT that were above the assay's limit of quantitation (LOQ); in contrast, 36%-63% of the subjects had preimmunization values of antibodies to FHA, PRN, or FIM that were above the LOQ. Substantial increases in titers of IgG and IgA antibodies to the 3 ACP antigens (PT, FHA, and PRN) were observed. Over the 18-months, the percent decay in IgG and IgA antibodies ranged from 56% to 73% and from 57% to 70%, respectively; the IgG antibody response and decay suggests that geometric mean titers likely remain above the LOQ for 2-9 years and above the threshold of detection for 4-13 years. These findings support the use of ACP booster immunizations for adolescents and adults, to provide sustained levels of antibody.
- Publication
Journal of Infectious Diseases, 2004, Vol 190, Issue 3, p535
- ISSN
0022-1899
- Publication type
Academic Journal
- DOI
10.1086/422035