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- Title
Sphingosine 1-phosphate induces antimicrobial activity both in vitro and in vivo.
- Authors
Garg, Sanjay K; Volpe, Elisabetta; Palmieri, Graziana; Mattei, Maurizio; Galati, Domenico; Martino, Angelo; Piccioni, Maria S; Valente, Emanuela; Bonanno, Elena; De Vito, Paolo; Baldini, Patrizia M; Spagnoli, Luigi G; Colizzi, Vittorio; Fraziano, Maurizio
- Abstract
Sphingosine 1-phosphate (S1P), a polar sphingolipid metabolite, is involved in a wide spectrum of biological processes, including Ca(++) mobilization, cell growth, differentiation, motility, and cytoskeleton organization. Here, we show a novel role of S1P in the induction of antimicrobial activity in human macrophages that leads to the intracellular killing of nonpathogenic Mycobacterium smegmatis and pathogenic M. tuberculosis. Such activity is mediated by host phospholipase D, which favors the acidification of mycobacteria-containing phagosomes. Moreover, when it was intravenously injected in mycobacteria-infected mice, S1P reduced mycobacterial growth and pulmonary tissue damage. These results identify S1P as a novel regulator of the host antimicrobial effector pathways.
- Publication
The Journal of infectious diseases, 2004, Vol 189, Issue 11, p2129
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/386286