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- Title
Nucleoside analogues and mitochondrial toxicity.
- Authors
Fleischer, Russell; Boxwell, Debra; Sherman, Kenneth E
- Abstract
An evaluation of the US Food and Drug Administration's Adverse Event Reporting System identified that patients coinfected with human immunodeficiency virus and chronic hepatitis C virus who were treated with a regimen of ribavirin and didanosine, with or without stavudine, were at increased risk for events associated with mitochondrial toxicity, including fatal hepatic failure, peripheral neuropathy, pancreatitis, and symptomatic hyperlactatemia/lactic acidosis. In response, the US product labels for didanosine and ribavirin have been revised to caution clinicians against coadministration of these drugs.
- Publication
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2004, Vol 38, Issue 8, pe79
- ISSN
1537-6591
- Publication type
Journal Article
- DOI
10.1086/383151