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- Title
Synonymous genetic polymorphisms within Brazilian human immunodeficiency virus Type 1 subtypes may influence mutational routes to drug resistance.
- Authors
Dumans, Ana T; Soares, Marcelo A; Machado, Elizabeth S; Hué, Stéphane; Brindeiro, Rodrigo M; Pillay, Deenan; Tanuri, Amilcar
- Abstract
Most published data on antiretroviral-drug resistance is generated from in vitro or in vivo studies of subtype B virus. However, this subtype is associated with <10% of HIV infections worldwide, and it is essential to explore subtype-specific determinants of drug resistance. One potential cause of the differences between subtypes is the synonymous codon usage at key resistance positions.
- Publication
The Journal of infectious diseases, 2004, Vol 189, Issue 7, p1232
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/382483