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- Title
Tenofovir-related Fanconi syndrome with nephrogenic diabetes insipidus in a patient with acquired immunodeficiency syndrome: the role of lopinavir-ritonavir-didanosine.
- Authors
Rollot, Florence; Nazal, Eve-Marie; Chauvelot-Moachon, Laurence; Kélaïdi, Charikleia; Daniel, Nathalie; Saba, Mona; Abad, Sebastien; Blanche, Philippe
- Abstract
Tenofovir-related tubular damage, like all other recently reported cases, occurred in patients receiving the protease inhibitor (PI) ritonavir, often with lopinavir. Increased plasma concentrations of didanosine were also observed after the addition of tenofovir. It was suspected that tenofovir with PIs interacted with renal organic anion transporters, leading to nephrotoxic tubular concentrations of tenofovir and systemic accumulation of didanosine. Until there is a better understanding of these interactions, close monitoring is recommended for patients receiving tenofovir, PIs, and didanosine.
- Publication
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2003, Vol 37, Issue 12, pe174
- ISSN
1537-6591
- Publication type
Journal Article
- DOI
10.1086/379829