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- Title
Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells.
- Authors
Levy, Ofer; Orange, Jordan S; Hibberd, Patricia; Steinberg, Sharon; LaRussa, Phillip; Weinberg, Adriana; Wilson, S Brian; Shaulov, Angela; Fleisher, Gary; Geha, Raif S; Bonilla, Francisco A; Exley, Mark
- Abstract
An 11-year-old girl presented with a papulovesicular rash and severe respiratory distress 5 weeks after receiving varicella vaccine. Restriction fragment length-polymorphism analysis of virus isolated from an endotracheal-tube aspirate and from bronchoalveolar lavage revealed that this patient's illness was due to the Oka vaccine strain of varicella. An extensive immunologic analysis failed to identify a known diagnostic entity to explain her susceptibility to this attenuated vaccine strain. Analysis of her lymphocytes on separate occasions, months after recovery from her illness, revealed a profound deficiency of natural killer T (NKT) cells and of NKT-cell activity, suggesting that NKT cells contribute to host defense against varicella virus.
- Publication
The Journal of infectious diseases, 2003, Vol 188, Issue 7, p948
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/378503