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- Title
Immunological and virological failure after antiretroviral therapy is associated with enhanced peripheral and thymic pathogenicity.
- Authors
Solomon, Ajantha; Cameron, Paul U; Bailey, Michael; Dunne, Amanda L; Crowe, Suzanne M; Hoy, Jenny F; Lewin, Sharon R
- Abstract
T cell dynamics and viral genotype were studied in human immunodeficiency virus 1-infected individuals receiving antiretroviral therapy who were viremic and had either increasing (discordant immunological responders) or decreasing (nonresponders) CD4(+) T cell counts. A comparison was made with treated individuals who were not viremic and had increasing CD4(+) T cell counts (complete responders). Nonresponders had higher CD4(+) T cell proliferation (as assessed by Ki67 expression) and immune activation (as assessed by CD38 and human leukocyte antigen-DR expression), together with a reduction in T cell receptor excision circles, compared with discordant immunological responders and complete responders, which suggests that there is enhanced viral pathogenicity in both peripheral T cells and the thymus. Although there was a high prevalence of mutations in the protease and reverse transcriptase genes in discordant immunological responders, these changes were also observed in nonresponders.
- Publication
The Journal of infectious diseases, 2003, Vol 187, Issue 12, p1915
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/375351