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- Title
Prediction of coronary heart disease risk in HIV-infected patients with fat redistribution.
- Authors
Hadigan, Colleen; Meigs, James B; Wilson, Peter W F; D'Agostino, Ralph B; Davis, Benjamin; Basgoz, Nesli; Sax, Paul E; Grinspoon, Steven
- Abstract
A metabolic syndrome has been described among human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy; the syndrome is characterized by fat redistribution, insulin resistance, and dyslipidemia. We compared the 10-year coronary heart disease (CHD) risk estimates for 91 HIV-infected men and women with fat redistribution with the risk estimates for 273 age-, sex-, and body mass index (BMI)-matched subjects enrolled in the Framingham Offspring Study. Thirty HIV-infected patients without fat redistribution were also compared with 90 age- and BMI-matched control subjects. The 10-year CHD risk estimate was significantly elevated among HIV-infected patients with fat redistribution, particularly among men; however, when they were matched with control subjects by waist-to-hip ratio, the 10-year CHD risk estimate did not significantly differ between groups. HIV-infected patients without fat redistribution did not have a greater CHD risk estimate than did control subjects. In addition, the CHD risk estimate was greatest in HIV-infected patients who had primary lipoatrophy, compared with those who had either lipohypertrophy or mixed fat redistribution. Therefore, although CHD risk is increased in HIV-infected patients with fat redistribution, the pattern of fat distribution and sex are potential important components in determining the risk in this population.
- Publication
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2003, Vol 36, Issue 7, p909
- ISSN
1537-6591
- Publication type
Journal Article
- DOI
10.1086/368185