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- Title
Postnatal human herpesvirus 8 and human immunodeficiency virus type 1 infection in mothers and infants from Zambia.
- Authors
Brayfield, Brad P; Phiri, Saul; Kankasa, Chipepo; Muyanga, Jubra; Mantina, Hamakwa; Kwenda, Geoffrey; West, John T; Bhat, Ganapati; Marx, Dave B; Klaskala, Winslow; Mitchell, Charles D; Wood, Charles
- Abstract
The specific route and timing of human herpesvirus (HHV) 8 infection in regions where Kaposi sarcoma is endemic are not known. HHV-8 infection and any risk factors that may be associated with HHV-8, including human immunodeficiency virus (HIV) type 1 infection, were monitored during the 12-month postdelivery period for 416 mothers and 485 infants from Lusaka, Zambia. HHV-8 incident infection rates during this period were 3.2 and 5.3 infections/100 person-years for infants and mothers, respectively. HHV-8 infection among infants was not associated with HHV-8 or HIV-1 infection in the mother. Among the HHV-8-positive infants, 2 of 12 tested were found to have HHV-8 DNA in their peripheral blood mononuclear cells at birth, which suggests that in utero infection is possible. However, most HHV-8-positive infants appeared to have acquired infection either intrapartum or postpartum. The present study indicates that transmission of HHV-8 to infants can occur early and is likely via multiple routes.
- Publication
The Journal of infectious diseases, 2003, Vol 187, Issue 4, p559
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/367985