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- Title
Long-Term Immunogenicity and Efficacy of Universal Hepatitis B Virus Vaccination in Taiwan.
- Authors
Yu-Cheng Lin; Mei-Hwei Chang; Yen-Hsuan Ni; Hong-Yuan Hsu; Ding-Shinn Chen
- Abstract
The long-term immunogenicity of universal hepatitis B virus (HBV) vaccine is seldom studied in large-scale prospective community-based populations, especially in adolescents. This study enrolled 1200 children aged 7 years with complete HBV immunization in infancy and determined HBV surface antigen (HBsAg), its antibody (anti-HBs), and HBV core antibody (anti-HBc) annually until the children were aged 14 years. Eleven children had new HBV infections with antiHBc positivity as the only marker. None became positive for HBsAg or had detectable HBV DNA by polymerase chain reaction. The percentage of protective anti-HBs in 951 children without booster vaccination gradually decreased from 71.1% at age 7 years to 37.4% at age 12 years. Only 1 of the 200 children in the booster group and 2 of the 258 children in the nonbooster group developed new anti-HBc positivity. The results suggest that routine booster vaccination may not be required to provide protection against chronic HBV infection before age 15 years.
- Publication
Journal of Infectious Diseases, 2003, Vol 187, Issue 1, p134
- ISSN
0022-1899
- Publication type
Academic Journal
- DOI
10.1086/345871