We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A novel methicillin-resistance cassette in community-acquired methicillin-resistant Staphylococcus aureus isolates of diverse genetic backgrounds.
- Authors
Daum, Robert S; Ito, Teruyo; Hiramatsu, Keiichi; Hussain, Farid; Mongkolrattanothai, Kanokporn; Jamklang, Mantana; Boyle-Vavra, Susan
- Abstract
Until recently, it has been unclear whether community-acquired (CA) methicillin-resistant Staphylococcus aureus (MRSA) isolates represent the spread of hospital MRSA isolates into the community. In 2 CA-MRSA isolates, a novel genetic element, designated staphylococcal cassette chromosome mec (SCCmec) type IV, was found; it differs from SCCmec types I-III in its small size and absence of non-beta-lactam genetic-resistance determinants. To study the prevalence of type IV SCCmec, polymerase chain reaction characterization of SCCmec was performed on DNA from 12 CA-MRSA isolates. The 12 CA-MRSA isolates were from diverse genetic backgrounds, as evidenced by their stratification into 5 pulsed-field gel electrophoresis types, 4 coagulase types, and 2 ribotypes. Eleven of the 12 isolates contained the novel SCCmec type IV element. Ten were resistant only to beta-lactam antibiotics. SCCmec type IV is present on the genome of CA-MRSA isolates. Its relatively small size and presence in isolates of diverse genetic backgrounds suggest that it may spread among S. aureus isolates.
- Publication
The Journal of infectious diseases, 2002, Vol 186, Issue 9, p1344
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/344326