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- Title
High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever.
- Authors
Libraty, Daniel H; Young, Paul R; Pickering, Darren; Endy, Timothy P; Kalayanarooj, Siripen; Green, Sharone; Vaughn, David W; Nisalak, Ananda; Ennis, Francis A; Rothman, Alan L
- Abstract
Infection with any 1 of 4 dengue viruses produces a spectrum of clinical illness ranging from a mild undifferentiated febrile illness to dengue fever (DF) to dengue hemorrhagic fever (DHF), a potentially life-threatening disease. The morbidity and mortality of DHF can be reduced by early hospitalization and careful supportive care. To determine its usefulness as a predictor of DHF, plasma levels of the secreted dengue virus nonstructural protein NS1 (sNS1) were measured daily in 32 children with dengue-2 virus infections participating in a prospective, hospital-based study. Free sNS1 levels in plasma correlated with viremia levels and were higher in patients with DHF than in those with DF. An elevated free sNS1 level (> or =600 ng/mL) within 72 h of illness onset identified patients at risk for developing DHF.
- Publication
The Journal of infectious diseases, 2002, Vol 186, Issue 8, p1165
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/343813