We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Adverse and beneficial secondary effects of mass treatment with azithromycin to eliminate blindness due to trachoma in Nepal.
- Authors
Fry, A M; Jha, H C; Lietman, T M; Chaudhary, J S P; Bhatta, R C; Elliott, J; Hyde, T; Schuchat, A; Gaynor, B; Dowell, S F
- Abstract
Mass administration of azithromycin to eliminate blindness due to trachoma has raised concerns regarding the emergence of antimicrobial resistance. During 2000, we compared the antimicrobial resistance of nasopharyngeal pneumococcal isolates recovered from and the prevalence of impetigo, respiratory symptoms, and diarrhea among 458 children in Nepal before and after mass administration of azithromycin. No azithromycin-resistant pneumococci were isolated except from 4.3% of children who had received azithromycin during 2 previous mass treatments (P<.001). There were decreases in the prevalence of impetigo (from 14% to 6% of subjects; adjusted odds ratio [OR], 0.41; 95% confidence interval [CI], 0.21-0.80) and diarrhea (from 32% to 11%; adjusted OR, 0.26; 95% CI, 0.14-0.43) 10 days after azithromycin treatment. The absence of macrolide-resistant isolates after 1 mass treatment with azithromycin is encouraging, although the recovery of azithromycin-resistant isolates after 2 mass treatments suggests the need for resistance monitoring when multiple rounds of antimicrobial treatment are given.
- Publication
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2002, Vol 35, Issue 4, p395
- ISSN
1537-6591
- Publication type
Journal Article
- DOI
10.1086/341414