We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Nitric oxide and cytokine synthesis in human African trypanosomiasis.
- Authors
MacLean, L; Odiit, M; Sternberg, J M
- Abstract
Plasma and cerebrospinal fluid (CSF) concentrations of nitrate and the cytokines interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, interleukin (IL)-10, and IL-4 were measured in 91 African trypanosomiasis patients before and after treatment. Nitrate levels overall were not significantly elevated over those for control persons, but a marginal increase in plasma nitrate was detected in patients reporting illness of <40 days' duration. Plasma IFN-gamma and total TNF-alpha concentrations increased during infection, but free TNF-alpha levels were low in all patients. The most dramatic cytokine response was for IL-10, which was significantly elevated in both plasma and CSF during infection but returned to control levels after treatment. The results indicate that human African trypanosomiasis leads to the development of a strong anti-inflammatory cytokine response.
- Publication
The Journal of infectious diseases, 2001, Vol 184, Issue 8, p1086
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/323479