We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Disorders of glucose metabolism in patients infected with human immunodeficiency virus.
- Authors
Dubé, M P
- Abstract
New-onset diabetes mellitus, clinically similar to type 2 diabetes, will affect a small proportion (1%-6%) of patients infected with human immunodeficiency virus (HIV) who are treated with HIV-1 protease inhibitors (PIs). However, insulin resistance and impaired glucose tolerance will develop during PI treatment in a considerable proportion of patients. Dyslipidemia, abdominal obesity, and loss of peripheral fat frequently coexist with insulin resistance, but it is not clear whether all of these result from a common pathogenic mechanism. Recent data suggest that insulin resistance may also be associated with HIV infection in patients not receiving PI therapy. The long-term consequences of insulin resistance in this population are not known. The effect of switching to other antiretroviral therapies has not been fully determined. Treatment of established diabetes mellitus should generally follow existing guidelines. There is no clinically useful screening test that will determine the existence and degree of insulin resistance in individual patients. It is therefore reasonable to recommend general measures to increase insulin sensitivity in all patients infected with HIV, such as weight reduction for obese persons and regular aerobic exercise.
- Publication
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2000, Vol 31, Issue 6, p1467
- ISSN
1058-4838
- Publication type
Journal Article
- DOI
10.1086/317491