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- Title
Comparison of human papillomavirus types 16, 18, and 6 capsid antibody responses following incident infection.
- Authors
Carter, J J; Koutsky, L A; Hughes, J P; Lee, S K; Kuypers, J; Kiviat, N; Galloway, D A
- Abstract
The relationship between human papillomavirus (HPV) DNA in the genital mucosa and serum IgG to HPV-16, -18, and -6 was studied in a cohort of 588 college women. Among women with incident HPV infections, 59.5%, 54.1%, and 68.8% seroconverted for HPV-16, -18, or -6, respectively, within 18 months of detecting the corresponding HPV DNA. Transient HPV DNA was associated with a failure to seroconvert following incident HPV infection; however, some women with persistent HPV DNA never seroconverted. Antibody responses to each type were heterogeneous, but several type-specific differences were found: seroconversion for HPV-16 occurred most frequently between 6 and 12 months of DNA detection, but seroconversion for HPV-6 coincided with DNA detection. Additionally, antibody responses to HPV-16 and -18 were significantly more likely to persist during follow-up than were antibodies to HPV-6.
- Publication
The Journal of infectious diseases, 2000, Vol 181, Issue 6, p1911
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/315498