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- Title
Lymphoproliferative responses to recombinant HIV-1 envelope antigens in neonates and infants receiving gp120 vaccines. AIDS Clinical Trial Group 230 Collaborators.
- Authors
Borkowsky, W; Wara, D; Fenton, T; McNamara, J; Kang, M; Mofenson, L; McFarland, E; Cunningham, C; Duliege, A M; Francis, D; Bryson, Y; Burchett, S; Spector, S A; Frenkel, L M; Starr, S; Van Dyke, R; Jimenez, E
- Abstract
Children of mothers infected with human immunodeficiency virus type 1 (HIV-1) were immunized at birth and at 1, 3, and 5 months with 1 of 3 doses of recombinant gp120 vaccines prepared from SF-2 or MN strains of HIV-1. A total of 126 children were not infected; 21 received adjuvant only. Vaccine recipients developed lymphoproliferative responses on >/=2 occasions, responding more often to homologous HIV-1 antigens than did adjuvant recipients (56% vs. 14%; P<.001). Responses were appreciated after 2 immunizations and were maintained for >84 weeks after the last immunization. An accelerated immunization schedule (birth, 2 weeks, 2 months, and 5 months) with the lowest dose of the SF-2 vaccine produced responses in all 11 vaccinees by 4 weeks. Responses to heterologous envelope antigens were also detected. Immune responses to vaccination are achievable at an age when some infection (perinatal or breast milk exposure related) may be prevented.
- Publication
The Journal of infectious diseases, 2000, Vol 181, Issue 3, p890
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/315298