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- Title
A novel surfactant nanoemulsion with broad-spectrum sporicidal activity against Bacillus species.
- Authors
Hamouda, T; Hayes, M M; Cao, Z; Tonda, R; Johnson, K; Wright, D C; Brisker, J; Baker, J R, Jr
- Abstract
Two nontoxic, antimicrobial nanoemulsions, BCTP and BCTP 401, have been developed. These emulsions are composed of detergents and oils in 80% water. BCTP diluted up to 1:1000 inactivated>90% of Bacillus anthracis spores in 4 h and was also sporicidal against three other Bacillus species. This sporicidal activity is due to disruption of the spore coat after initiation of germination without complete outgrowth. BCTP 401 diluted 1:1000 had greater activity than BCTP against Bacillus spores and had an onset of action of <30 min. Mixing BCTP or BCTP 401 with Bacillus cereus prior to subcutaneous injection in mice reduced the resulting skin lesion by 99%. Wound irrigation with BCTP 1 h after spore inoculation yielded a 98% reduction in skin lesion size, and mortality was reduced 3-fold. These nanoemulsion formulas are stable, easily dispersed, nonirritant, and nontoxic compared with other available sporicidal agents.
- Publication
The Journal of infectious diseases, 1999, Vol 180, Issue 6, p1939
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/315124