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- Title
Human immunodeficiency virus type 1 subtypes differ in disease progression.
- Authors
Kanki, P J; Hamel, D J; Sankalé, J L; Hsieh, C c; Thior, I; Barin, F; Woodcock, S A; Guèye-Ndiaye, A; Zhang, E; Montano, M; Siby, T; Marlink, R; NDoye, I; Essex, M E; MBoup, S
- Abstract
At least 10 different genetic human immunodeficiency virus type 1 (HIV-1) subtypes (A-J) are responsible for the AIDS pandemic. Much of the understanding of HIV-1 disease progression derives from studies in the developed world where HIV infection is almost exclusively subtype B. This has led many to question whether the properties and consequences of HIV-1 infection can be generalized across subtypes that afflict the majority of infected persons in the developing world. From 1985 to 1997, a prospective study of registered female sex workers in Senegal tracked the introduction and spread of HIV-1 subtypes A, C, D, and G. In clinical follow-up, the AIDS-free survival curves differed by HIV-1 subtype. Women infected with a non-A subtype were 8 times more likely to develop AIDS than were those infected with subtype A (hazard ratio=8.23; P=. 009), the predominant subtype in the study. These data suggest that HIV-1 subtypes may differ in rates of progression to AIDS.
- Publication
The Journal of infectious diseases, 1999, Vol 179, Issue 1, p68
- ISSN
0022-1899
- Publication type
Journal Article
- DOI
10.1086/314557