We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Coronary artery disease and human immunodeficiency virus infection.
- Authors
Passalaris, J D; Sepkowitz, K A; Glesby, M J
- Abstract
Recent reports of myocardial infarctions in young persons infected with human immunodeficiency virus (HIV) who are receiving protease inhibitor therapy have raised concerns about premature coronary artery disease in this population. Endothelial dysfunction, hypercoagulability, hypertriglyceridemia, and abnormal coronary artery pathology were in fact associated with HIV infection prior to the availability of protease inhibitor therapy. Newly recognized risk factors, such as insulin resistance, hypercholesterolemia, and fat redistribution syndrome, may exacerbate underlying atherosclerotic risk for patients receiving protease inhibitors. Data on the incidence of myocardial infarction among these patients are largely limited to case reports but are of concern. Pending the availability of further data, it is prudent to monitor these patients for hyperlipidemia and consider interventions to modify cardiac risk factors.
- Publication
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2000, Vol 31, Issue 3, p787
- ISSN
1058-4838
- Publication type
Journal Article
- DOI
10.1086/313995