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- Title
Severe pneumococcal pneumonia in previously healthy children: the role of preceding influenza infection.
- Authors
O'Brien, K L; Walters, M I; Sellman, J; Quinlisk, P; Regnery, H; Schwartz, B; Dowell, S F
- Abstract
An outbreak of severe pneumococcal pneumonia among children occurred in Iowa from November 1995 through January 1996. An associated outbreak of influenza disease was predominantly caused by influenza A (H1N1) for the first time since 1989. We conducted a case-control study to determine whether preceding influenza infection was directly associated with pneumococcal illness. We identified 13 children with severe pneumococcal pneumonia. Patients were more likely than control subjects to report experiencing an influenza-like illness in the 7-28 days preceding admission (matched odds ratio [OR], 12.4; 95% confidence interval [CI], 1.7-306). Likewise, family members of patients were more likely than those of control subjects to report experiencing an influenza-like illness in the 28 days preceding their admission date (OR, 2.6; 95% CI, 1.0-6. 3). Patients were more likely than control subjects to have a positive influenza A (H1N1) convalescent serology (matched OR, 3.7; 95% CI, 1.0-18.1). This study provides direct and indirect evidence that influenza infection led to severe pneumococcal pneumonia among these children. Prevention of pneumococcal disease should be included among the potential benefits of influenza vaccination.
- Publication
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2000, Vol 30, Issue 5, p784
- ISSN
1058-4838
- Publication type
Journal Article
- DOI
10.1086/313772