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- Title
Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope.
- Authors
Daniel, Carolin; Weigmann, Benno; Bronson, Roderick; von Boehmer, Harald
- Abstract
Type 1 diabetes (T1D) results from the destruction of insulin-secreting pancreatic β cells by autoreactive T cells. Insulin is an essential target of the autoimmune attack. Insulin epitopes recognized by diabetogenic T cell clones bind poorly to the class II I-A(g7) molecules of nonobese diabetic (NOD) mice, which results in weak agonistic activity of the peptide MHC complex. Here, we describe a strongly agonistic insulin mimetope that effectively converts naive T cells into Foxp3(+) regulatory T cells in vivo, thereby completely preventing T1D in NOD mice. In contrast, natural insulin epitopes are ineffective. Subimmunogenic vaccination with strongly agonistic insulin mimetopes might represent a novel strategy to prevent T1D in humans at risk for the disease.
- Publication
The Journal of experimental medicine, 2011, Vol 208, Issue 7, p1501
- ISSN
1540-9538
- Publication type
Journal Article
- DOI
10.1084/jem.20110574