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- Title
Hemophagocytosis causes a consumptive anemia of inflammation.
- Authors
Zoller, Erin E; Lykens, Jennifer E; Terrell, Catherine E; Aliberti, Julio; Filipovich, Alexandra H; Henson, Peter M; Jordan, Michael B
- Abstract
Cytopenias of uncertain etiology are commonly observed in patients during severe inflammation. Hemophagocytosis, the histological appearance of blood-eating macrophages, is seen in the disorder hemophagocytic lymphohistiocytosis and other inflammatory contexts. Although it is hypothesized that these phenomena are linked, the mechanisms facilitating acute inflammation-associated cytopenias are unknown. We report that interferon γ (IFN-γ) is a critical driver of the acute anemia observed during diverse microbial infections in mice. Furthermore, systemic exposure to physiologically relevant levels of IFN-γ is sufficient to cause acute cytopenias and hemophagocytosis. Demonstrating the significance of hemophagocytosis, we found that IFN-γ acts directly on macrophages in vivo to alter endocytosis and provoke blood cell uptake, leading to severe anemia. These findings define a unique pathological process of broad clinical and immunological significance, which we term the consumptive anemia of inflammation.
- Publication
The Journal of experimental medicine, 2011, Vol 208, Issue 6, p1203
- ISSN
1540-9538
- Publication type
Journal Article
- DOI
10.1084/jem.20102538