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- Title
miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice.
- Authors
Boldin, Mark P; Taganov, Konstantin D; Rao, Dinesh S; Yang, Lili; Zhao, Jimmy L; Kalwani, Manorama; Garcia-Flores, Yvette; Luong, Mui; Devrekanli, Asli; Xu, Jessica; Sun, Guizhen; Tay, Jia; Linsley, Peter S; Baltimore, David
- Abstract
Excessive or inappropriate activation of the immune system can be deleterious to the organism, warranting multiple molecular mechanisms to control and properly terminate immune responses. MicroRNAs (miRNAs), ∼22-nt-long noncoding RNAs, have recently emerged as key posttranscriptional regulators, controlling diverse biological processes, including responses to non-self. In this study, we examine the biological role of miR-146a using genetically engineered mice and show that targeted deletion of this gene, whose expression is strongly up-regulated after immune cell maturation and/or activation, results in several immune defects. Collectively, our findings suggest that miR-146a plays a key role as a molecular brake on inflammation, myeloid cell proliferation, and oncogenic transformation.
- Publication
The Journal of experimental medicine, 2011, Vol 208, Issue 6, p1189
- ISSN
1540-9538
- Publication type
Journal Article
- DOI
10.1084/jem.20101823