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- Title
Erythropoietin protects against diabetes through direct effects on pancreatic beta cells.
- Authors
Choi, Diana; Schroer, Stephanie A; Lu, Shun Yan; Wang, Linyuan; Wu, Xiaohong; Liu, Yunfeng; Zhang, Yi; Gaisano, Herbert Y; Wagner, Kay-Uwe; Wu, Hong; Retnakaran, Ravi; Woo, Minna
- Abstract
A common feature among all forms of diabetes mellitus is a functional β-cell mass insufficient to maintain euglycemia; therefore, the promotion of β-cell growth and survival is a fundamental goal for diabetes prevention and treatment. Evidence has suggested that erythropoietin (EPO) exerts cytoprotective effects on nonerythroid cells. However, the influence of EPO on pancreatic β cells and diabetes has not been evaluated to date. In this study, we report that recombinant human EPO treatment can protect against diabetes development in streptozotocin-induced and db/db mouse models of type 1 and type 2 diabetes, respectively. EPO exerts antiapoptotic, proliferative, antiinflammatory, and angiogenic effects within the islets. Using β-cell-specific EPO receptor and JAK2 knockout mice, we show that these effects of EPO result from direct biological effects on β cells and that JAK2 is an essential intracellular mediator. Thus, promotion of EPO signaling in β cells may be a novel therapeutic strategy for diabetes prevention and treatment.
- Publication
The Journal of experimental medicine, 2010, Vol 207, Issue 13, p2831
- ISSN
1540-9538
- Publication type
Journal Article
- DOI
10.1084/jem.20100665